WAY-181,187

WAY-181,187
	File:WAY-181187-structure.png
Systematic (IUPAC) name
	1-[(2S,5S)-4,4-difluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
Identifiers
CAS Number	?
ATC code	none
PubChem	CID 509512
ChemSpider	444760
Chemical data
Formula	C9H10F2N2O4
Molar mass	248.18 g/mol[[Script error: No such module "String".]]
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WAY-181,187 is a high affinity and selective 5-HT₆ receptor full agonist.^[1]^[2] It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas.^[1]^[3] WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder,^[4]^[1] though it has also been shown to impair cognition and memory.^[5]^[3]

References

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