Pimavanserin

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Pimavanserin
File:ACP-103 structure.png
Systematic (IUPAC) name
N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide
Clinical data
Routes of
administration
Oral
Identifiers
CAS Number 706779-91-1
ATC code none
PubChem CID 10071196
Chemical data
Formula C25H34FN3O2
Molar mass 427.553 g/mol[[Script error: No such module "String".]]
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Pimavanserin (ACP-103) is a drug developed by Acadia Pharmaceuticals which acts as an inverse agonist on the serotonin receptor subtype 5-HT2A, with 10x selectivity over 5-HT2C, and no significant affinity or activity at 5-HT2B or dopamine receptors.[1] As of September 3 2009, pimavanserin has not met expectations for Phase III clinical trials for the treatment of Parkinson's disease psychosis,[2] and is in Phase II trials for adjunctive treatment of schizophrenia alongside an antipsychotic medication.[3] It is expected to improve the effectiveness and side effect profile of antipsychotics.[4][5][6]

References

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  2. ACADIA Pharmaceuticals. "Treating Parkinson's Disease - Clinical Trial Pimavanserin - ACADIA". Retrieved 2009-04-11. 
  3. "ACADIA Announces Positive Results From ACP-103 Phase II Schizophrenia Co-Therapy Trial" (Press release). ACADIA Pharmaceuticals. 2007-03-19. http://news.acadia-pharm.com/phoenix.zhtml?c=125180&p=irol-newsArticle&ID=974982&highlight=. Retrieved 2009-04-11. 
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