RH-34

RH-34
	File:RH-34 structure.png
Systematic (IUPAC) name
	3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
Clinical data
Routes of; administration	?
Legal status
Legal status	Uncontrolled;
Identifiers
CAS Number	?
ATC code	none
PubChem	CID 10041987
Chemical data
Formula	C18H19N3O3
Molar mass	325.361 g/mol[[Script error: No such module "String".]]
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RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT_2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT_2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT_2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT_2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.^[1]^[2]

References

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