RH-34

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RH-34
File:RH-34 structure.png
Systematic (IUPAC) name
3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
Clinical data
Routes of
administration
?
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number ?
ATC code none
PubChem CID 10041987
Chemical data
Formula C18H19N3O3
Molar mass 325.361 g/mol[[Script error: No such module "String".]]
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RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.[1][2]

See also

References

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  1. Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  2. Maria Silva PhD. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.