Mesembrine
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| Mesembrine | |
|---|---|
| (3aS,7aR)-3a- (3,4-dimethoxyphenyl)- 1-methyl-2,3,4,5,7,7a- hexahydroindol-6-one | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| CAS number | 468-53-1 |
| PubChem | 193296 |
| SMILES | Script error: No such module "collapsible list". |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C17H23NO3 |
| Molar mass | 289.37 g mol−1 |
| log P | 1.1 |
| style="background: #F8EABA; text-align: center;" colspan="2" | Supplementary data page | |
| Structure and properties |
n, εr, etc. |
| Thermodynamic data |
Phase behaviour Solid, liquid, gas |
| Spectral data | UV, IR, NMR, MS |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Mesembrine is an alkaloid present in Sceletium tortuosum.[1] Mesembrine acts as a serotonin reuptake inhibitor[2], as well as a PDE4 inhibitor.[3] Mesembrine may contribute to the antidepressant effects of kanna.
References
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parameter "group" is allowed only.
<references />, or <references group="..." />| PDE1 | |
|---|---|
| PDE2 | |
| PDE3 | Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • Quazinone • RPL-554 • Siguazodan • Trequinsin • Vesnarinone • Zardaverine |
| PDE4 | Arofylline • Cilomilast • CP-80633 • Denbutylline • Drotaverine • Etazolate • Filaminast • Glaucine • HT-0712 • Ibudilast • ICI-63197 • Irsogladine • Mesembrine • Pentoxifylline • Propentofylline • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976 |
| PDE5 | Acetildenafil • Avanafil • Dipyridamole • Icariin • Lodenafil • Mirodenafil • MY-5445 • Sildenafil • T-0156 • Tadalafil • Thiomethisosildenafil • Udenafil • Vardenafil |
| PDE6 | |
| PDE7 | |
| PDE9 | |
| PDE10 | |
| Nonselective | |
fr:Mésembrine
uk:Месембрін
- ↑ Smith M, Crouch N, Gericke N, Hirst M (1996). "Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review". Journal of Ethnopharmacology. 50 (3): 119–30. doi:10.1016/0378-8741(95)01342-3. PMID 8691846. CS1 maint: Multiple names: authors list (link)
- ↑ Gary I. Stafforda, Mikael E. Pedersenb, Johannes van Stadena, Anna K. Jäger (2008). "Review on plants with CNS-effects used in traditional South African medicine against mental diseases". Journal of Ethnopharmacology. 119 (3): 513–537. doi:10.1016/j.jep.2008.08.010. PMID 18775771. CS1 maint: Multiple names: authors list (link)
- ↑ Mesembrine - an inhibitor of PDE4 that follows structure-activity relationship to rolipram. [1]
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