Binedaline
| File:Binedaline.png | |
| Systematic (IUPAC) name | |
|---|---|
|
N,N,N-trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine | |
| Clinical data | |
| Routes of administration | Oral |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | 60662-16-0 |
| ATC code | none |
| PubChem | CID 42509 |
| ChemSpider | 38769 |
| Chemical data | |
| Formula | C19H24ClN3 |
| Molar mass | 329.86696 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Binedaline (Ixprim), also called binodaline, is a drug that was being investigated as an antidepressant in the 1980s but never marketed.[1][2] It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters.[3] It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.[3]
References
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| Pyrrolidines | |
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See also Sympathomimetic amines | |
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- ↑ Faltus; Geerling, FC (1984). "A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression". Neuropsychobiology. 12 (1): 34–8. doi:10.1159/000118107. PMID 6239991. edit
- ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ↑ 3.0 3.1 Morin; Zini, R; Urien, S; Tillement, JP (1989). "Pharmacological profile of binedaline, a new antidepressant drug". The Journal of pharmacology and experimental therapeutics. 249 (1): 288–96. PMID 2540319. edit
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