SL65.0155

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SL65.0155
150px
Systematic (IUPAC) name
5-(5-amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-(1-phenethyl-4-piperidyl)-1,3,4-oxadiazol-2-one hydrochloride
Identifiers
CAS Number ?
ATC code none
PubChem CID 9805718
ChemSpider 7981478
Chemical data
Formula C23H26Cl2N4O4
Molar mass 493.38 g/mol[[Script error: No such module "String".]]
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SL65.0155 is a selective 5-HT4 receptor partial agonist (Ki = 0.6 nM; IA = 40-50% (relative to 5-HT)).[1] It potently enhances cognition, learning, and memory,[1][2][3][4][5][6] and also possesses antidepressant effects.[7] SL65.0155 was in phase II clinical trials around 2004-2006 for the treatment of memory deficits and dementia but no new information has surfaced since and it appears to have been abandoned.[8][9]

See also

References

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Anticholinesterases
Others

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc, drug(N5A/5B/5C/6A/6B/6D)

Acetylcholinesterases
Ampakines
CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-404,187 • LY-503,430 • PEPA • Sunifiram • Unifiram
D1 Agonists
Eugeroics
GABAA α5 Inverse Agonists
H3 Antagonists
mACh Agonists
nACh Agonists
Racetams
Others


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  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ Spencer JP, Brown JT, Richardson JC; et al. (2004). "Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease". Neuroscience. 129 (1): 49–54. doi:10.1016/j.neuroscience.2004.06.070. PMID 15489027. 
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  8. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  9. ↑ Roth, Bryan L. (2006). The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics (The Receptors). Totowa, NJ: Humana Press. ISBN 1-58829-568-0. 
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