Pheniramine

Pheniramine

File:Pheniramine.svg
Systematic (IUPAC) name
N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
Clinical data
Pregnancy category	A
Routes of administration	Oral
Pharmacokinetic data
Metabolism	Hepatic hydroxylation, demethylation and glucuronidation
Excretion	Renal
Identifiers
CAS Number	86-21-5
ATC code	R06AB05 (WHO)
PubChem	CID 4761
Chemical data
Formula	C16H20N2
Molar mass	240.343 g/mol[[]]
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Pheniramine (Avil) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.

Chemical relatives

Derivatives of pheniramine include chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, deschlorpheniramine, triprolidine, and brompheniramine. Two other halogenated derivatives, iodopheniramine and fluorpheniramine, are currently in use for research on combination therapies for malaria and some cancers. The halogenation of pheniramine increases its potency by 20-fold.

Side effects

Avil may cause drowsiness, and over-dosage may lead to sleep disorders. Overdose may lead to seizures, especially in combination with alcohol.

External links

• Leaflet on Avil by The Royal Australian College of General Practitioners

pl:Feniramina