Naphthylpiperazine

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Naphthylpiperazine
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Systematic (IUPAC) name
1-(naphthalen-1-yl)piperazine
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 57536-86-4
ATC code none
PubChem CID 1342
IUPHAR/BPS 3
ChemSpider 1302
Chemical data
Formula C14H16N2
Molar mass 212.29 g/mol[[Script error: No such module "String".]]
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1-(-1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors,[1][2][3] while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors.[4][5][6] It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors,[7][8][9][10] and may bind to 5-HT4 and the SERT as well.[11][12] In animals it produces effects including hyperphagia,[13][14][15] hyperactivity,[16][17] and anxiolysis,[17][18][19][20] of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.

See also

References

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  8. Wesołowska A (2002). "In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors". Polish Journal of Pharmacology. 54 (4): 327–41. PMID 12523486. 
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  13. Kennett GA, Curzon G (1988). "Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors". Psychopharmacology. 96 (1): 93–100. PMID 2906446. 
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  15. Schechter LE, Simansky KJ (1988). "1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats". Psychopharmacology. 94 (3): 342–6. PMID 3128809. 
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  17. 17.0 17.1 Kennett GA (1992). "5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model". Psychopharmacology. 107 (2-3): 379–84. PMID 1352056. 
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  19. Gibson EL, Barnfield AM, Curzon G (1994). "Evidence that mCPP-induced anxiety in the plus-maze is mediated by postsynaptic 5-HT2C receptors but not by sympathomimetic effects". Neuropharmacology. 33 (3-4): 457–65. PMID 7984284. 
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