5-HT1F receptor
From Self-sufficiency
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| 5-hydroxytryptamine (serotonin) receptor 1F | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HTR1F; 5-HT1F; HTR1EL; MR77 | ||||||||||||
| External IDs | OMIM: 182134 MGI: 99842 HomoloGene: 37361 IUPHAR: 5-HT1F GeneCards: HTR1F Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3355 | 15557 | |||||||||||
| Ensembl | ENSG00000179097 | ENSMUSG00000050783 | |||||||||||
| UniProt | P30939 | Q543V2 | |||||||||||
| RefSeq (mRNA) | NM_000866 | NM_008310 | |||||||||||
| RefSeq (protein) | NP_000857 | NP_032336 | |||||||||||
| Location (UCSC) | Chr 3: 88.12 - 88.12 Mb | Chr 16: 64.87 - 65.05 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.[1][2][3][4][5]
Contents
Ligands
Agonists
- BRL-54443 - mixed 5-HT1E/1F agonist
- Eletriptan - mixed 5-HT1B/1D/1E/1F/2B/7 agonist
- LY-334,370[6] - as well as related benzamides[7]
- LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
- Naratriptan - mixed 5-HT1B/1D/1F agonist
Antagonists
No selective 5HT1F antagonists are available as yet.
See also
References
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- "5-HT1F". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors". Pharmacol. Biochem. Behav. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546.
- Raymond JR, Mukhin YV, Gelasco A; et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537.
- Amlaiky N, Ramboz S, Boschert U; et al. (1992). "Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus". J. Biol. Chem. 267 (28): 19761–4. PMID 1328180.
- Adham N, Kao HT, Schecter LE; et al. (1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408–12. doi:10.1073/pnas.90.2.408. PMC 45671 Freely accessible. PMID 8380639.
- Lovenberg TW, Erlander MG, Baron BM; et al. (1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184–8. doi:10.1073/pnas.90.6.2184. PMC 46050 Freely accessible. PMID 8384716.
- Maassen VanDenBrink A, Vergouwe MN, Ophoff RA; et al. (1999). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". Am. J. Med. Genet. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Bhatnagar A, Sheffler DJ, Kroeze WK; et al. (2004). "Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors". J. Biol. Chem. 279 (33): 34614–23. doi:10.1074/jbc.M404673200. PMID 15190056.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Hannula-Jouppi K, Kaminen-Ahola N, Taipale M; et al. (2006). "The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia". PLoS Genet. 1 (4): e50. doi:10.1371/journal.pgen.0010050. PMC 1270007 Freely accessible. PMID 16254601.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Mol. Membr. Biol. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). "[3H]-LY-334,370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510.
- ↑ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorg. Med. Chem. Lett. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.
