Lesopitron
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File:Lesopitron.png | |
Systematic (IUPAC) name | |
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2-{4-[4-(4-chloro-1H-pyrazol-1-yl)butyl]piperazin-1-yl}pyrimidine | |
Clinical data | |
Routes of administration | Oral |
Legal status | |
Legal status |
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Identifiers | |
CAS Number | 132449-46-8 |
ATC code | none |
PubChem | CID 60813 |
ChemSpider | 54801 |
Chemical data | |
Formula | C15H21ClN6 |
Molar mass | 320.82 g/mol[[Script error: No such module "String".]] |
Script error: No such module "collapsible list". | |
Lesopitron (E-4424) is a selective full agonist of the 5-HT1A receptor which is structurally related to the azapirones.[1] In 2001 it was under development by Esteve as an anxiolytic for the treatment of generalized anxiety disorder (GAD).[2][3] It made it to phase II clinical trials but was apparently discontinued as no new information on lesopitron has surfaced since.[2][3]
See also
References
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GABAA PAMs |
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α2δ VDCC Blockers | |||||||||||
5-HT1A Agonists | |||||||||||
H1 Antagonists | Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine | ||||||||||
CRH1 Antagonists | |||||||||||
NK2 Antagonists | |||||||||||
MCH1 antagonists | |||||||||||
mGluR2/3 Agonists | |||||||||||
mGluR5 NAMs | |||||||||||
TSPO agonists | |||||||||||
σ1 agonists | |||||||||||
Others | Benzoctamine • Carbetocin • Demoxytocin • Mephenoxalone • Mepiprazole • Oxanamide • Oxytocin • Promoxolane • Tofisopam • Trimetozine • WAY-267,464 | ||||||||||
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