Zalospirone

Zalospirone
	File:Zalospirone.svg
Systematic (IUPAC) name
	(3aα,4α,4aβ,6aβ,7α,7aα)-hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-etheno-1H-cyclobut(f)isoindole-1,3(2H)-dione
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Pharmacokinetic data
Biological half-life	1-4 hours
Identifiers
CAS Number	114298-18-9
ATC code	none
PubChem	CID 163925
IUPHAR/BPS	58
Chemical data
Formula	C24H29N5O2
Molar mass	419.519 g/mol[[Script error: No such module "String".]]
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Zalospirone (WY-47,846) is a selective 5-HT_1A partial agonist of the azapirone chemical class.^[1]^[2] It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.^[3]

References

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↑ Gleeson S, Barrett JE. 5-HT1A agonist effects on punished responding of squirrel monkeys. Pharmacology, Biochemistry and Behaviour. 1990 Oct;37(2):335-7. PMID 1981937
↑ Singh A, Lucki I. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. PMID 8497336
↑ Rickels K, Derivan A, Kunz N, Pallay A, Schweizer E. Zalospirone in major depression: a placebo-controlled multicenter study. Journal of Clinical Psychopharmacology. 1996 Jun;16(3):212-7. PMID 8784652

[1] Gleeson S, Barrett JE. 5-HT1A agonist effects on punished responding of squirrel monkeys. Pharmacology, Biochemistry and Behaviour. 1990 Oct;37(2):335-7. PMID 1981937

[2] Singh A, Lucki I. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40. PMID 8497336

[3] Rickels K, Derivan A, Kunz N, Pallay A, Schweizer E. Zalospirone in major depression: a placebo-controlled multicenter study. Journal of Clinical Psychopharmacology. 1996 Jun;16(3):212-7. PMID 8784652

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v t e Piperazines
Simple piperazines (no additional rings)	1-Cyclohexylpiperazine • Aminoethylpiperazine • Diethylcarbamazine • HEPPS • Midafotel • Piperazine • PIPES
Phenylpiperazines	Acaprazine • Antrafenine • Aripiprazole • Batoprazine • Bifeprunox • BRL-15,572 • Ciprofloxacin • CSP-2503 • Dapiprazole • DCPP • DMPP • Dropropizine • EGIS-12,233 • Elopiprazole • Eltoprazine • Enpiprazole • Ensaculin • Etoperidone • Flesinoxan • Flibanserin • Fluprazine • Itraconazole • Ketoconazole • Levodropropizine • Lorpiprazole • mCPP • MeOPP • Mepiprazole • Naftopidil • Naphthylpiperazine • Nefazodone • Niaprazine • Oxypertine • Pardoprunox • pCPP • pFPP • Posaconazole • PRX-00023 • S-14,506 • S-14,671 • S-15,535 • SB-258,585 • SB-271,046 • SB-357,134 • SB-399,885 • Sonepiprazole • TFMPP • Tolpiprazole • Trazodone • Urapidil • Vesnarinone • Vilazodone • WAY-100,135 • WAY-100,635
Benzylpiperazines	2C-B-BZP • Befuraline • Bifeprunox • Buclizine • BZP • Chlorbenzoxamine • DBZP • Fipexide • Imatinib • MBZP • MDBZP • Meclozine • Piberaline • Piribedil • Trimetazidine • Vesnarinone
Diphenylalkylpiperazines (benzhydrylalkylpiperazines)	Almitrine • Amperozide • BRL-15,572 • Buclizine • BW373U86 • Cetirizine • Chlorbenzoxamine • Chlorcyclizine • Cinnarizine • Clocinizine • Cyclizine • DBL-583 • Diphenylmethylpiperazine • Dotarizine • DPI-221 • DPI-287 • DPI-3290 • GBR-12,783 • GBR-12,935 • GBR-13,069 • GBR-13,098 • GBR-13,119 • Hydroxyzine • Lidoflazine • Manidipine • Meclozine • Oxatomide • SNC-80 • Vanoxerine
Pyrimidinylpiperazines	Buspirone • Dasatinib • Eptapirone • Gepirone • Ipsapirone • Piribedil • Pyrimidinylpiperazine • Revospirone • Tandospirone • Tirilazad • Trimazosin • Umespirone • Zalospirone
Pyridinylpiperazines	Atevirdine • Azaperone • Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone • Perospirone • Revospirone • Tiospirone • Ziprasidone
Tricyclics (piperazine attached via side chain)	Amoxapine • Clopenthixol • Clozapine • Flupentixol • Fluphenazine • Loxapine • Olanzapine • Opipramol • Perazine • Perphenazine • Pirenzepine • Prochlorperazine • Thiethylperazine • Thiothixene • Trifluoperazine • Zuclopenthixol
Others	6-Nitroquipazine • Azimilide • Cinepazet • Cyclohexylpiperazine • Hexocyclium • Indinavir • JNJ-7777120 • Lodenafil • Mirodenafil • PB-28 • Quipazine • Ranolazine • SA-4503 • Sildenafil • Tadalafil • Vardenafil • VUF-6002 • Zipeprol

Zalospirone

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References

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