Bombesin-like receptor 3

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Bombesin-like receptor 3
Identifiers
SymbolsBRS3;
External IDsOMIM300107 MGI1100501 HomoloGene1307 IUPHAR: BB3 GeneCards: BRS3 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez68012209
EnsemblENSG00000102239ENSMUSG00000031130
UniProtP32247O54798
RefSeq (mRNA)NM_001727NM_009766
RefSeq (protein)NP_001718NP_033896
Location (UCSC)Chr X:
135.4 - 135.4 Mb
Chr X:
53.39 - 53.4 Mb
PubMed search[1][2]

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally-occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]

References

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Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. Jump up "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. Jump up to: 2.0 2.1 2.2 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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  4. Jump up "Entrez Gene: BRS3 bombesin-like receptor 3". 
  5. Jump up Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344. 
  6. Jump up Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428Freely accessible. PMID 18055507.