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Taste receptor, type 1, member 3
SymbolsTAS1R3; T1R3
External IDsOMIM605865 MGI1933547 HomoloGene12890 GeneCards: TAS1R3 Gene
RefSeq (mRNA)NM_152228NM_031872
RefSeq (protein)NP_689414NP_114078
Location (UCSC)Chr 1:
1.26 - 1.26 Mb
Chr 4:
154.7 - 154.71 Mb
PubMed search[1][2]

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene.[1][2]

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.[supplied by OMIM][2]

See also


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Further reading

  • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952. 
  • Max M, Shanker YG, Huang L; et al. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac". Nat. Genet. 28 (1): 58–63. doi:10.1038/88270. PMID 11326277. 
  • Nelson G, Chandrashekar J, Hoon MA; et al. (2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099. 
  • Li X, Staszewski L, Xu H; et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMC 123709Freely accessible. PMID 11917125. 
  • Spadaccini R, Trabucco F, Saviano G; et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI". J. Mol. Biol. 328 (3): 683–92. doi:10.1016/S0022-2836(03)00346-2. PMID 12706725. 
  • Ariyasu T, Matsumoto S, Kyono F; et al. (2004). "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose". In Vitro Cell. Dev. Biol. Anim. 39 (1-2): 80–8. doi:10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2. PMID 12892531. 
  • Jiang P, Ji Q, Liu Z; et al. (2004). "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins". J. Biol. Chem. 279 (43): 45068–75. doi:10.1074/jbc.M406779200. PMID 15299024. 
  • Xu H, Staszewski L, Tang H; et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMC 521102Freely accessible. PMID 15353592. 
  • Taniguchi K (2005). "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas". J. Vet. Med. Sci. 66 (11): 1311–4. doi:10.1292/jvms.66.1311. PMID 15585941. 
  • Jiang P, Cui M, Zhao B; et al. (2005). "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste". J. Biol. Chem. 280 (15): 15238–46. doi:10.1074/jbc.M414287200. PMID 15668251. 
  • Galindo-Cuspinera V, Winnig M, Bufe B; et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'". Nature. 441 (7091): 354–7. doi:10.1038/nature04765. PMID 16633339. 
  • Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Behrens M, Bartelt J, Reichling C; et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576. 
  • Koizumi A, Nakajima K, Asakura T; et al. (2007). "Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain". Biochem. Biophys. Res. Commun. 358 (2): 585–9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  2. 2.0 2.1 "Entrez Gene: TAS1R3 taste receptor, type 1, member 3".