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Taste receptor, type 2, member 14
SymbolsTAS2R14; MGC125491; MGC125492; T2R14; TRB1
External IDsOMIM604790 MGI2681298 HomoloGene87013 GeneCards: TAS2R14 Gene
RefSeq (mRNA)NM_023922NM_021562
RefSeq (protein)NP_076411NP_067537
Location (UCSC)Chr 12:
11.09 - 11.32 Mb
Chr 6:
133.02 - 133.02 Mb
PubMed search[1][2]

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.[1][2][3]


This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, TAS2R14 responds to (-)-α-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries.[4] This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

See also


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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  3. 3.0 3.1 "Entrez Gene: TAS2R14 taste receptor, type 2, member 14". 
  4. Behrens, M., A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig, and W. Meyerhof (2004). "The human taste receptor hTAS2R14 responds to a variety of different bitter compounds". Biochem Biophys Res Commun. 319 (2): 479–485. doi:10.1016/j.bbrc.2004.05.019. PMID 15178431.