Niacin receptor 2

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niacin receptor 2
SymbolsNIACR2; GPR109B; HM74; PUMAG; Puma-g
External IDsOMIM606039 HomoloGene55944 IUPHAR: GeneCards: NIACR2 Gene
RefSeq (mRNA)NP_006009n/a
RefSeq (protein)NM_006018n/a
Location (UCSC)Chr 12:
121.77 - 121.77 Mb
PubMed search[1]n/a

Niacin receptor 2, also known as NIACR2 or GPR109B, is a protein which in humans is encoded by the NIACR2 gene.[1][2]


GPR109B is a low affinity receptor for nicotinic acid (niacin)[3] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).

GPR109B is a Gi /Go protein-coupled receptor with low affinity for nicotinic acid.[3]


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External links

Further reading

  • Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Zingoni A, Rocchi M, Storlazzi CT; et al. (1997). "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor". Genomics. 42 (3): 519–23. doi:10.1006/geno.1997.4754. PMID 9205127. 
  • Irobi J, Nelis E, Verhoeven K; et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wise A, Foord SM, Fraser NJ; et al. (2003). "Molecular identification of high and low affinity receptors for nicotinic acid". J. Biol. Chem. 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 
  • Tunaru S, Kero J, Schaub A; et al. (2003). "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect". Nat. Med. 9 (3): 352–5. doi:10.1038/nm824. PMID 12563315. 
  • Soga T, Kamohara M, Takasaki J; et al. (2003). "Molecular identification of nicotinic acid receptor". Biochem. Biophys. Res. Commun. 303 (1): 364–9. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Toulza E, Mattiuzzo NR, Galliano MF; et al. (2007). "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology. 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMID 17562024. 
  1. "Entrez Gene: GPR109B G protein-coupled receptor 109B". 
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