Niacin receptor 2

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niacin receptor 2
Identifiers
SymbolsNIACR2; GPR109B; HM74; PUMAG; Puma-g
External IDsOMIM: 606039 HomoloGene: 55944 IUPHAR: GeneCards: NIACR2 Gene
Orthologs
SpeciesHumanMouse
Entrez8843n/a
EnsemblENSG00000182782n/a
UniProtP49019n/a
RefSeq (mRNA)NP_006009n/a
RefSeq (protein)NM_006018n/a
Location (UCSC)Chr 12:
121.77 - 121.77 Mb		n/a
PubMed search[1]n/a

Niacin receptor 2, also known as NIACR2 or GPR109B, is a protein which in humans is encoded by the NIACR2 gene.[1][2]

Function

GPR109B is a low affinity receptor for nicotinic acid (niacin)[3] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).

GPR109B is a Gi /Go protein-coupled receptor with low affinity for nicotinic acid.[3]

References

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External links

Further reading

  • Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Zingoni A, Rocchi M, Storlazzi CT; et al. (1997). "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor". Genomics. 42 (3): 519–23. doi:10.1006/geno.1997.4754. PMID 9205127. 
  • Irobi J, Nelis E, Verhoeven K; et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wise A, Foord SM, Fraser NJ; et al. (2003). "Molecular identification of high and low affinity receptors for nicotinic acid". J. Biol. Chem. 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 
  • Tunaru S, Kero J, Schaub A; et al. (2003). "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect". Nat. Med. 9 (3): 352–5. doi:10.1038/nm824. PMID 12563315. 
  • Soga T, Kamohara M, Takasaki J; et al. (2003). "Molecular identification of nicotinic acid receptor". Biochem. Biophys. Res. Commun. 303 (1): 364–9. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Toulza E, Mattiuzzo NR, Galliano MF; et al. (2007). "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology. 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMID 17562024. 
Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
40x30px This article on a gene on chromosome 12 is a stub. You can help ssf by expanding it.
  1. ↑ "Entrez Gene: GPR109B G protein-coupled receptor 109B". 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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