LPHN3
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Latrophilin 3 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | LPHN3; CIRL3; LEC3 | ||||||||||||
External IDs | MGI: 2441950 HomoloGene: 22878 IUPHAR: LPHN3 GeneCards: LPHN3 Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 23284 | 319387 | |||||||||||
Ensembl | ENSG00000150471 | ENSMUSG00000037605 | |||||||||||
UniProt | Q9HAR2 | Q80TS3 | |||||||||||
RefSeq (mRNA) | NM_015236 | NM_198702 | |||||||||||
RefSeq (protein) | NP_056051 | NP_941991 | |||||||||||
Location (UCSC) | Chr 4: 62.05 - 62.62 Mb | Chr 5: 82.1 - 82.87 Mb | |||||||||||
PubMed search | [1] | [2] |
Latrophilin-3 is a protein that in humans is encoded by the LPHN3 gene.[1][2]
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[2]
See also
References
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Further reading
- Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annu. Rev. Neurosci. 24: 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
- Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
- Soares MB, Bonaldo MF, Jelene P; et al. (1994). "Construction and characterization of a normalized cDNA library". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. doi:10.1073/pnas.91.20.9228. PMC 44785 Freely accessible. PMID 7937745.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
- Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
- Kreienkamp HJ, Zitzer H, Gundelfinger ED; et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ 2.0 2.1 "Entrez Gene: LPHN3 latrophilin 3".