GPR34
From Self-sufficiency
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G protein-coupled receptor 34 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | GPR34; | ||||||||||||
External IDs | OMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 2857 | 23890 | |||||||||||
Ensembl | ENSG00000171659 | ENSMUSG00000040229 | |||||||||||
UniProt | Q9UPC5 | Q3USC5 | |||||||||||
RefSeq (mRNA) | NM_001033513 | NM_011823 | |||||||||||
RefSeq (protein) | NP_001028685 | NP_035953 | |||||||||||
Location (UCSC) | Chr X: 41.43 - 41.44 Mb | Chr X: 12.79 - 12.8 Mb | |||||||||||
PubMed search | [1] | [2] |
Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[1][2][3]
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][3]
References
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Further reading
- Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Jacobi FK, Broghammer M, Pesch K; et al. (2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Hum. Genet. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.
- Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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- ↑ Jump up to: 3.0 3.1 "Entrez Gene: GPR34 G protein-coupled receptor 34".