Formyl peptide receptor 2

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Formyl peptide receptor 2
Identifiers
SymbolsFPR2; FPRL1; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; HM63; LXA4R
External IDsOMIM: 136538 MGI: 1278319 HomoloGene: 74395 IUPHAR: FPR2/ALX GeneCards: FPR2 Gene
RNA expression pattern
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez235814289
EnsemblENSG00000171049ENSMUSG00000052270
UniProtP25090O88536
RefSeq (mRNA)NM_001005738NM_008039
RefSeq (protein)NP_001005738NP_032065
Location (UCSC)Chr 19:
56.96 - 56.97 Mb		Chr 17:
18.02 - 18.03 Mb
PubMed search[1][2]

N-formyl peptide receptor 2 is a protein that in humans is encoded by the FPR2 gene.[1][2]


See also

References

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External links

Further reading

  • Murphy PM, Ozçelik T, Kenney RT; et al. (1992). "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family". J. Biol. Chem. 267 (11): 7637–43. PMID 1373134. 
  • Ye RD, Cavanagh SL, Quehenberger O; et al. (1992). "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor". Biochem. Biophys. Res. Commun. 184 (2): 582–9. doi:10.1016/0006-291X(92)90629-Y. PMID 1374236. 
  • Perez HD, Holmes R, Kelly E; et al. (1992). "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils". Gene. 118 (2): 303–4. doi:10.1016/0378-1119(92)90208-7. PMID 1511907. 
  • Bao L, Gerard NP, Eddy RL; et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Durstin M, Gao JL, Tiffany HL; et al. (1994). "Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes". Biochem. Biophys. Res. Commun. 201 (1): 174–9. doi:10.1006/bbrc.1994.1685. PMID 8198572. 
  • Takano T, Fiore S, Maddox JF; et al. (1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors". J. Exp. Med. 185 (9): 1693–704. doi:10.1084/jem.185.9.1693. PMID 9151906. 
  • Gronert K, Gewirtz A, Madara JL, Serhan CN (1998). "Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release". J. Exp. Med. 187 (8): 1285–94. doi:10.1084/jem.187.8.1285. PMID 9547339. 
  • Deng X, Ueda H, Su SB; et al. (1999). "A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R". Blood. 94 (4): 1165–73. PMID 10438703. 
  • Chiang N, Fierro IM, Gronert K, Serhan CN (2000). "Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation". J. Exp. Med. 191 (7): 1197–208. doi:10.1084/jem.191.7.1197. PMID 10748237. 
  • Shen W, Proost P, Li B; et al. (2000). "Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines". Biochem. Biophys. Res. Commun. 272 (1): 276–83. doi:10.1006/bbrc.2000.2770. PMID 10872839. 
  • Le Y, Jiang S, Hu J; et al. (2000). "N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes". Clin. Immunol. 96 (3): 236–42. doi:10.1006/clim.2000.4896. PMID 10964542. 
  • De Yang , Chen Q, Schmidt AP; et al. (2000). "LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells". J. Exp. Med. 192 (7): 1069–74. doi:10.1084/jem.192.7.1069. PMID 11015447. 
  • Kang Y, Taddeo B, Varai G; et al. (2000). "Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling". Biochemistry. 39 (44): 13551–7. doi:10.1021/bi001196i. PMID 11063592. 
  • Svensson L, Dahlgren C, Wennerås C (2002). "The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1". J. Leukoc. Biol. 72 (4): 810–8. PMID 12377951. 
  • He R, Sang H, Ye RD (2003). "Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R". Blood. 101 (4): 1572–81. doi:10.1182/blood-2002-05-1431. PMID 12393391. 
  • Christophe T, Karlsson A, Rabiet MJ; et al. (2002). "Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4". Scand. J. Immunol. 56 (5): 470–6. doi:10.1046/j.1365-3083.2002.01149.x. PMID 12410796. 
  • Kucharzik T, Gewirtz AT, Merlin D; et al. (2003). "Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium". Am. J. Physiol., Cell Physiol. 284 (4): C888–96. doi:10.1152/ajpcell.00507.2001. PMID 12456400. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
40x30px This transmembrane receptor-related article is a stub. You can help ssf by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ "Entrez Gene: FPRL1 Formyl peptide receptor-like 1". 
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