Neuromedin B receptor

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Neuromedin B receptor
Identifiers
SymbolsNMBR;
External IDsOMIM: 162341 MGI: 1100525 HomoloGene: 20560 IUPHAR: BB1 GeneCards: NMBR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez482918101
EnsemblENSG00000135577ENSMUSG00000019865
UniProtP28336Q0VEH1
RefSeq (mRNA)NM_002511NM_008703
RefSeq (protein)NP_002502NP_032729
Location (UCSC)Chr 6:
142.44 - 142.45 Mb		Chr 10:
14.45 - 14.46 Mb
PubMed search[1][2]

The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B [2].

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3]

References

  1. ↑ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
  2. ↑ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  3. ↑ "Entrez Gene: NMBR neuromedin B receptor". 

Further reading

  • Corjay MH, Dobrzanski DJ, Way JM; et al. (1991). "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells". J. Biol. Chem. 266 (28): 18771–9. PMID 1655761. 
  • Wu JM, Hoang DO, Feldman RI (1995). "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs". Mol. Pharmacol. 47 (4): 871–81. PMID 7723750. 
  • Benya RV, Kusui T, Pradhan TK; et al. (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118. 
  • Bitar KN, Zhu XX (1994). "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction". Gastroenterology. 105 (6): 1672–80. PMID 8253343. 
  • Giladi E, Nagalla SR, Spindel ER (1993). "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides". J. Mol. Neurosci. 4 (1): 41–54. doi:10.1007/BF02736689. PMID 8391296. 
  • Fathi Z, Benya RV, Shapira H; et al. (1993). "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding". J. Biol. Chem. 268 (20): 14622–6. PMID 8392057. 
  • Kane MA, Toi-Scott M, Johnson GL; et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. 
  • Sainz E, Akeson M, Mantey SA; et al. (1998). "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor". J. Biol. Chem. 273 (26): 15927–32. doi:10.1074/jbc.273.26.15927. PMID 9632639. 
  • Lee S, Kim Y (1999). "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy". FEBS Lett. 460 (2): 263–9. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Matusiak D, Glover S, Nathaniel R; et al. (2005). "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. doi:10.1152/ajpgi.00156.2004. PMID 15528253. 

External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
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