P2RY1

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Purinergic receptor P2Y, G-protein coupled, 1
Identifiers
SymbolsP2RY1; P2Y1
External IDsOMIM601167 MGI105049 HomoloGene1926 IUPHAR: P2Y1 GeneCards: P2RY1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez502818441
EnsemblENSG00000169860ENSMUSG00000027765
UniProtP47900Q544J5
RefSeq (mRNA)NM_002563NM_008772
RefSeq (protein)NP_002554NP_032798
Location (UCSC)Chr 3:
154.04 - 154.04 Mb
Chr 3:
61.09 - 61.1 Mb
PubMed search[1][2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also

References

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External links

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

pt:P2RY1 sr:P2RY1
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  2. "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".