FZD8

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Frizzled homolog 8 (Drosophila)
250px
PDB rendering based on 1ijy.
Identifiers
SymbolsFZD8; FZ-8; hFZ8
External IDsOMIM606146 MGI108460 HomoloGene40606 IUPHAR: FZD8 GeneCards: FZD8 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez832514370
EnsemblENSG00000177283ENSMUSG00000036904
UniProtQ9H461Q61091
RefSeq (mRNA)NM_031866NM_008058
RefSeq (protein)NP_114072NP_032084
Location (UCSC)Chr 10:
35.97 - 35.97 Mb
Chr 18:
9.21 - 9.21 Mb
PubMed search[1][2]

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

See also

References

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External links

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  2. 2.0 2.1 "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".