Formyl peptide receptor 1

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Formyl peptide receptor 1
Identifiers
SymbolsFPR1; FMLP; FPR
External IDsOMIM136537 MGI107443 HomoloGene20466 IUPHAR: FPR1 GeneCards: FPR1 Gene
RNA expression pattern
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez235714293
EnsemblENSG00000171051ENSMUSG00000045551
UniProtP21462Q3UV01
RefSeq (mRNA)NM_002029NM_013521
RefSeq (protein)NP_002020NP_038549
Location (UCSC)Chr 19:
56.94 - 56.95 Mb
Chr 17:
17.58 - 17.59 Mb
PubMed search[1][2]

fMet-Leu-Phe receptor also known as the N-formyl peptide receptor is a protein that in humans is encoded by the FPR1 gene.[1][2][3]

See also

References

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Further reading

  • Graves V, Gabig T, McCarthy L; et al. (1992). "Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils". Blood. 80 (3): 776–87. PMID 1322204. 
  • Murphy PM, Ozçelik T, Kenney RT; et al. (1992). "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family". J. Biol. Chem. 267 (11): 7637–43. PMID 1373134. 
  • Perez HD, Holmes R, Kelly E; et al. (1992). "Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression". Biochemistry. 31 (46): 11595–9. doi:10.1021/bi00161a044. PMID 1445895. 
  • Bao L, Gerard NP, Eddy RL; et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Murphy PM, McDermott D (1991). "Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor". J. Biol. Chem. 266 (19): 12560–7. PMID 1712023. 
  • Boulay F, Tardif M, Brouchon L, Vignais P (1991). "The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors". Biochemistry. 29 (50): 11123–33. doi:10.1021/bi00502a016. PMID 2176894. 
  • Wahl SM, Allen JB, Gartner S; et al. (1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". J. Immunol. 142 (10): 3553–9. PMID 2541200. 
  • Jesaitis AJ, Naemura JR, Painter RG; et al. (1983). "Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes". Biochim. Biophys. Acta. 719 (3): 556–68. PMID 6129903. 
  • Prossnitz ER, Kim CM, Benovic JL, Ye RD (1995). "Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2". J. Biol. Chem. 270 (3): 1130–7. doi:10.1074/jbc.270.3.1130. PMID 7836371. 
  • Klotz KN, Jesaitis AJ (1994). "Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization". Biochem. Pharmacol. 48 (6): 1297–300. doi:10.1016/0006-2952(94)90168-6. PMID 7945424. 
  • Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ (1994). "Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity". Biochim. Biophys. Acta. 1209 (1): 69–76. PMID 7947984. 
  • Murphy PM, Tiffany HL, McDermott D, Ahuja SK (1993). "Sequence and organization of the human N-formyl peptide receptor-encoding gene". Gene. 133 (2): 285–90. doi:10.1016/0378-1119(93)90653-K. PMID 8224916. 
  • Jesaitis AJ, Erickson RW, Klotz KN; et al. (1993). "Functional molecular complexes of human N-formyl chemoattractant receptors and actin". J. Immunol. 151 (10): 5653–65. PMID 8228254. 
  • Särndahl E, Bokoch GM, Boulay F; et al. (1996). "Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton". J. Biol. Chem. 271 (25): 15267–71. doi:10.1074/jbc.271.25.15267. PMID 8663057. 
  • Maestes DC, Potter RM, Prossnitz ER (1999). "Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor". J. Biol. Chem. 274 (42): 29791–5. doi:10.1074/jbc.274.42.29791. PMID 10514456. 
  • Liang TS, Wang JM, Murphy PM, Gao JL (2000). "Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils". Biochem. Biophys. Res. Commun. 270 (2): 331–5. doi:10.1006/bbrc.2000.2416. PMID 10753626. 
  • Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. PMID 10820279. 
  • Bennett TA, Maestas DC, Prossnitz ER (2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence". J. Biol. Chem. 275 (32): 24590–4. doi:10.1074/jbc.C000314200. PMID 10823817. 
  • Ayala JM, Goyal S, Liverton NJ; et al. (2000). "Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway". J. Leukoc. Biol. 67 (6): 869–75. PMID 10857861. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  3. "Entrez Gene: FPR1 formyl peptide receptor 1".