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G protein-coupled receptor 35
External IDsOMIM602646 MGI1929509 HomoloGene3874 IUPHAR: GPR35 GeneCards: GPR35 Gene
RNA expression pattern
More reference expression data
RefSeq (mRNA)NM_005301NM_022320
RefSeq (protein)NP_005292NP_071715
Location (UCSC)Chr 2:
241.22 - 241.22 Mb
Chr 1:
94.62 - 94.82 Mb
PubMed search[1][2]

G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene[1] Hightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.


One study has shown that kynurenic acid acts as an endogenous ligand for this receptor.[2] Zaprinast, a PDE5A inhibitor, was found to be an agonist for GPR35.[3]

Clinical significance

Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome.[4] In one study GPR35 has been recognised as a potential oncogene in the stomach cancer.[5]


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  1. O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). "Discovery of three novel G-protein-coupled receptor genes". Genomics. 47 (2): 310–3. doi:10.1006/geno.1998.5095. PMID 9479505. 
  2. Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). "Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35". J. Biol. Chem. 281 (31): 22021–8. doi:10.1074/jbc.M603503200. PMID 16754668. free fulltext
  3. Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). "Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35". FEBS Lett. 580 (21): 5003–8. doi:10.1016/j.febslet.2006.08.015. PMID 16934253. 
  4. Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). "Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype". Clin. Genet. 66 (6): 537–44. doi:10.1111/j.1399-0004.2004.00363.x. PMID 15521982. 
  5. Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). "Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells". Cancer Sci. 95 (2): 131–5. doi:10.1111/j.1349-7006.2004.tb03193.x. PMID 14965362.