GPR143

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G protein-coupled receptor 143
Identifiers
SymbolsGPR143; OA1
External IDsOMIM300500 MGI107193 HomoloGene230 IUPHAR: GPR143 GeneCards: GPR143 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez493518241
EnsemblENSG00000101850ENSMUSG00000025333
UniProtP51810Q549B6
RefSeq (mRNA)NM_000273NM_010951
RefSeq (protein)NP_000264NP_035081
Location (UCSC)Chr X:
9.65 - 9.69 Mb
Chr X:
148.12 - 148.15 Mb
PubMed search[1][2]

G-protein coupled receptor 143 is a protein that in humans is encoded by the GPR143 gene.[1][2][3]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[3]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor[4][5].

Interactions

GPR143 has been shown to interact with GNAI1.[2]

References

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External links

Further reading


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  2. 2.0 2.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. 3.0 3.1 "Entrez Gene: GPR143 G protein-coupled receptor 143". 
  4. Vetrini F, Auricchio A, Du J; et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell Biol. 24 (15): 6550–9. doi:10.1128/MCB.24.15.6550-6559.2004. PMC 444869Freely accessible. PMID 15254223. 
  5. Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.