F2RL3

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Coagulation factor II (thrombin) receptor-like 3
Identifiers
SymbolsF2RL3; PAR4
External IDsOMIM602779 MGI1298207 HomoloGene36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez900214065
EnsemblENSG00000127533ENSMUSG00000050147
UniProtQ96RI0Q0VDX1
RefSeq (mRNA)NM_003950NM_007975
RefSeq (protein)NP_003941NP_032001
Location (UCSC)Chr 19:
16.86 - 16.87 Mb
Chr 8:
75.66 - 75.66 Mb
PubMed search[1][2]

Protease-activated receptor 4 (PAR4), previously known as Coagulation factor II (thrombin) receptor-like 3, is a protein encoded by the F2RL3 gene in humans.[1]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. 1.0 1.1 "Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3".