Secretin receptor
From Self-sufficiency
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Secretin receptor | |||||||||||||
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Identifiers | |||||||||||||
Symbols | SCTR; SR | ||||||||||||
External IDs | OMIM: 182098 HomoloGene: 68290 IUPHAR: secretin GeneCards: SCTR Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
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More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 6344 | n/a | |||||||||||
Ensembl | ENSG00000080293 | n/a | |||||||||||
UniProt | P47872 | n/a | |||||||||||
RefSeq (mRNA) | NM_002980 | n/a | |||||||||||
RefSeq (protein) | NP_002971 | n/a | |||||||||||
Location (UCSC) | Chr 2: 119.91 - 120 Mb | n/a | |||||||||||
PubMed search | [1] | n/a |
Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]
Interactions
Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.[2]
References
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Further reading
- Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology. 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500.
- Felley CP, Qian JM, Mantey S; et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692.
- Ishihara T, Nakamura S, Kaziro Y; et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". EMBO J. 10 (7): 1635–41. PMC 452832 Freely accessible. PMID 1646711.
- Robberecht P, De Neef P, Waelbroeck M; et al. (1988). "Secretin receptors in human pancreatic membranes". Pancreas. 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683.
- Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008.
- Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244.
- Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". J. Biol. Chem. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300.
- Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochem. Biophys. Res. Commun. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894.
- Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245.
- Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics. 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789.
- Vilardaga JP, di Paolo E, de Neef P; et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602.
- Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & signal transduction. 7 (3): 143–50. PMID 9440501.
- Shetzline MA, Premont RT, Walker JK; et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". J. Biol. Chem. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976.
- Ho PK, Fong RS, Kai HS; et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Lett. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774.
- Pang RT, Ng SS, Cheng CH; et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology. 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138.
- Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology. 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Pang RT, Lee LT, Ng SS; et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
External links
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