Relaxin receptor

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relaxin/insulin-like family peptide receptor 1
Identifiers
Symbol RXFP1
Alt. symbols LGR7
Entrez 59350
HUGO 19718
OMIM 606654
RefSeq NM_021634
UniProt Q9HBX9
Other data
Locus Chr. 4 q31.3
relaxin/insulin-like family peptide receptor 2
Identifiers
Symbol RXFP2
Alt. symbols LGR8, GREAT, GPR106, INSL3R
Entrez 122042
HUGO 17318
OMIM 606655
RefSeq NM_130806
UniProt Q8WXD0
Other data
Locus Chr. 13 q12.3
relaxin/insulin-like family peptide receptor 3
Identifiers
Symbol RXFP3
Alt. symbols RLN3R1, SALPR, GPCR135
Entrez 51289
HUGO 24883
OMIM 609445
RefSeq NM_016568
UniProt Q9NSD7
Other data
Locus Chr. 5 p15.1-p14
relaxin/insulin-like family peptide receptor 4
Identifiers
Symbol RXFP4
Alt. symbols GPR100, GPCR142, RLN3R2
Entrez 339403
HUGO 14666
OMIM 609043
RefSeq NM_181885
UniProt Q8TDU9
Other data
Locus Chr. 1 q22

The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]

Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.

receptor/gene ligands activates inhibits
RXFP1 Relaxin 1, Relaxin 2, Relaxin 3 adenylate cyclase, protein kinase A, protein kinase C,

phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)

RXFP2 Relaxin 1, Relaxin 2, INSL3 adenylate cyclase
RXFP3 Relaxin 3 Erk1/2 signaling adenylate cyclase
RXFP4 Relaxin 3, INSL3 adenylate cyclase

References

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External links

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Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. 
  2. ↑ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861 Freely accessible. PMID 17293890. 
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