Cysteinyl leukotriene receptor 2

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Cysteinyl leukotriene receptor 2
Identifiers
Symbols	CYSLTR2; GPCR; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; PSEC0146; hGPCR21
External IDs	OMIM: 605666 MGI: 1917336 HomoloGene: 10688 IUPHAR: CysLT2 GeneCards: CYSLTR2 Gene
Gene Ontology Molecular function • cysteinyl leukotriene receptor activity • receptor activity Cellular component • cellular_component • membrane • integral to membrane Biological process • immune response • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57105	70086
Ensembl	ENSG00000152207	ENSMUSG00000033470
UniProt	Q9NS75	Q8R528
RefSeq (mRNA)	NM_020377	NM_133720
RefSeq (protein)	NP_065110	NP_598481
Location (UCSC)	Chr 13: 48.18 - 48.18 Mb	Chr 14: 71.76 - 71.78 Mb
PubMed search	[1]	[2]

Cysteinyl leukotriene receptor 2 is a protein that in humans is encoded by the CYSLTR2 gene.

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.

See also

• Eicosanoid receptor

External links

• "Leukotriene Receptors: CysLT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Nothacker HP, Wang Z, Zhu Y; et al. (2001). "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist". Mol. Pharmacol. 58 (6): 1601–8. PMID 11093801. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils". Clin. Exp. Allergy. 31 (11): 1714–23. doi:10.1046/j.1365-2222.2001.01184.x. PMID 11696047. CS1 maint: Multiple names: authors list (link)
• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shirasaki H, Kanaizumi E, Watanabe K; et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa". Clin. Exp. Allergy. 32 (7): 1007–12. doi:10.1046/j.1365-2222.2002.01425.x. PMID 12100046. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sjöström M, Johansson AS, Schröder O; et al. (2004). "Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells". Arterioscler. Thromb. Vasc. Biol. 23 (8): e37–41. doi:10.1161/01.ATV.0000082689.46538.DF. PMID 12816881. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mellor EA, Frank N, Soler D; et al. (2003). "Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R". Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11589–93. doi:10.1073/pnas.2034927100. PMC 208802 Freely accessible. PMID 13679572. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thompson MD, Storm van's Gravesande K, Galczenski H; et al. (2004). "A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha". Pharmacogenetics. 13 (10): 641–9. doi:10.1097/01.fpc.0000054127.14659.42. PMID 14515063. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288 Freely accessible. PMID 15057823. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukai H, Ogasawara Y, Migita O; et al. (2005). "Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma". Pharmacogenetics. 14 (10): 683–90. doi:10.1097/00008571-200410000-00006. PMID 15454733. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pillai SG, Cousens DJ, Barnes AA; et al. (2005). "A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma". Pharmacogenetics. 14 (9): 627–33. doi:10.1097/00008571-200409000-00007. PMID 15475736. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hui Y, Cheng Y, Smalera I; et al. (2005). "Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure". Circulation. 110 (21): 3360–6. doi:10.1161/01.CIR.0000147775.50954.AA. PMID 15545522. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corrigan C, Mallett K, Ying S; et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". J. Allergy Clin. Immunol. 115 (2): 316–22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uzonyi B, Lötzer K, Jahn S; et al. (2006). "Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6326–31. doi:10.1073/pnas.0601223103. PMC 1458877 Freely accessible. PMID 16606835. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woszczek G, Chen LY, Nagineni S; et al. (2007). "IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes". J. Immunol. 178 (8): 5262–70. PMID 17404310. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klotsman M, York TP, Pillai SG; et al. (2007). "Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast". Pharmacogenet. Genomics. 17 (3): 189–96. doi:10.1097/FPC.0b013e3280120043. PMID 17460547. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.