Brain-specific angiogenesis inhibitor 2

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Brain-specific angiogenesis inhibitor 2
Identifiers
Symbols	BAI2;
External IDs	OMIM: 602683 MGI: 2451244 HomoloGene: 1288 IUPHAR: BAI2 GeneCards: BAI2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • brain-specific angiogenesis inhibitor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • neuropeptide signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	576	230775
Ensembl	ENSG00000121753	ENSMUSG00000028782
UniProt	O60241	Q80T36
RefSeq (mRNA)	NM_001703	NM_173071
RefSeq (protein)	NP_001694	NP_775094
Location (UCSC)	Chr 1: 31.97 - 32 Mb	Chr 4: 129.49 - 129.52 Mb
PubMed search	[1]	[2]

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

Further reading

• Kreienkamp HJ, Zitzer H, Gundelfinger ED; et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kee HJ, Koh JT, Kim MY; et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. doi:10.1097/00004647-200209000-00003. PMID 12218411. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petersen HH, Hilpert J, Militz D; et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adkins JN, Varnum SM, Auberry KJ; et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics. 1 (12): 947–55. PMID 12543931. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242. 
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 Freely accessible. PMID 16344560. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.