FZD7

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Frizzled homolog 7 (Drosophila)
Identifiers
SymbolsFZD7; FzE3
External IDsOMIM603410 MGI108570 HomoloGene20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
RNA expression pattern
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez832414369
EnsemblENSG00000155760ENSMUSG00000041075
UniProtO75084Q6P551
RefSeq (mRNA)NM_003507NM_008057
RefSeq (protein)NP_003498NP_032083
Location (UCSC)Chr 2:
202.61 - 202.61 Mb
Chr 1:
59.43 - 59.43 Mb
PubMed search[1][2]

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[3]

Interactions

FZD7 has been shown to interact with DLG4.[4]

See also

References

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External links

  • "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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