GPR3

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G protein-coupled receptor 3
Identifiers
SymbolsGPR3; ACCA
External IDsOMIM600241 MGI101908 HomoloGene31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez282714748
EnsemblENSG00000181773ENSMUSG00000049649
UniProtP46089Q3USD4
RefSeq (mRNA)NM_005281NM_008154
RefSeq (protein)NP_005272NP_032180
Location (UCSC)Chr 1:
27.59 - 27.59 Mb
Chr 4:
132.48 - 132.48 Mb
PubMed search[1][2]

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.[1][1][2] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand.[3] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.[4] While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.[5]

References

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Further reading


  1. 1.0 1.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. "Entrez Gene: GPR3 G protein-coupled receptor 3". 
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