Prostaglandin E receptor 3

From Self-sufficiency
Jump to: navigation, search
edit
Prostaglandin E receptor 3 (subtype EP3)
Identifiers
SymbolsPTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302
External IDsOMIM176806 MGI97795 HomoloGene22622 IUPHAR: EP3 GeneCards: PTGER3 Gene
RNA expression pattern
250px
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez573319218
EnsemblENSG00000050628ENSMUSG00000040016
UniProtP43115P30557
RefSeq (mRNA)NM_000957NM_011196
RefSeq (protein)NP_000948NP_035326
Location (UCSC)Chr 1:
71.09 - 71.29 Mb
Chr 3:
157.5 - 157.58 Mb
PubMed search[1][2]

Prostaglandin E receptor 3, also known as EP3, is a prostaglandin receptor, encoded by the PTGER3 gene.[1]

Receptor

The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.

Variations

Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[1]

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. 1.0 1.1 "Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)".