CD97

From Self-sufficiency
Jump to: navigation, search
edit
CD97 molecule
250px
PDB rendering based on 2bo2.
Identifiers
SymbolsCD97; TM7LN1
External IDsOMIM601211 MGI1347095 HomoloGene8050 IUPHAR: CD97 GeneCards: CD97 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez97626364
EnsemblENSG00000123146ENSMUSG00000002885
UniProtP48960Q9Z0M6
RefSeq (mRNA)NM_001025160NM_011925
RefSeq (protein)NP_001020331NP_036055
Location (UCSC)Chr 19:
14.35 - 14.38 Mb
Chr 8:
86.61 - 86.63 Mb
PubMed search[1][2]

CD97 antigen is a protein that in humans is encoded by the CD97 gene.[1][2][3]

This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.[3]

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

Further reading

  • Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  • Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. 3.0 3.1 "Entrez Gene: CD97 CD97 molecule".