P2RY4

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Pyrimidinergic receptor P2Y, G-protein coupled, 4
Identifiers
Symbols	P2RY4; NRU; P2P; P2Y4; UNR
External IDs	OMIM: 300038 MGI: 1926594 HomoloGene: 20568 IUPHAR: P2Y4 GeneCards: P2RY4 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • UTP-activated nucleotide receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • elevation of cytosolic calcium ion concentration • transepithelial chloride transport Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5030	57385
Ensembl	ENSG00000186912	ENSMUSG00000044359
UniProt	P51582	Q0VBT7
RefSeq (mRNA)	NM_002565	NM_020621
RefSeq (protein)	NP_002556	NP_065646
Location (UCSC)	Chr X: 69.39 - 69.4 Mb	Chr X: 96.79 - 96.8 Mb
PubMed search	[1]	[2]

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.

The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.

See also

• P2Y receptor

External links

• "P2Y Receptors: P2Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Nguyen T, Erb L, Weisman GA; et al. (1996). "Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene". J. Biol. Chem. 270 (52): 30845–8. doi:10.1074/jbc.270.52.30845. PMID 8537335. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stam NJ, Klomp J, Van de Heuvel N, Olijve W (1996). "Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor". FEBS Lett. 384 (3): 260–4. doi:10.1016/0014-5793(96)00321-3. PMID 8617367. CS1 maint: Multiple names: authors list (link)
• Nicholas RA, Watt WC, Lazarowski ER; et al. (1996). "Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor". Mol. Pharmacol. 50 (2): 224–9. PMID 8700127. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704. CS1 maint: Multiple names: authors list (link)
• Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMC 1565225 Freely accessible. PMID 9535005. CS1 maint: Multiple names: authors list (link)
• Brinson AE, Harden TK (2001). "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor". J. Biol. Chem. 276 (15): 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308. 
• Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B (2001). "Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor". Eur. J. Pharmacol. 416 (3): 197–202. doi:10.1016/S0014-2999(01)00875-5. PMID 11290369. CS1 maint: Multiple names: authors list (link)
• Moore DJ, Chambers JK, Wahlin JP; et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1-3): 107–19. PMID 11690642. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Idzko M, Dichmann S, Ferrari D; et al. (2002). "Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors". Blood. 100 (3): 925–32. doi:10.1182/blood.V100.3.925. PMID 12130504. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. CS1 maint: Multiple names: authors list (link)
• Kim SG, Soltysiak KA, Gao ZG; et al. (2003). "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors". Biochem. Pharmacol. 65 (6): 923–31. doi:10.1016/S0006-2952(02)01614-3. PMID 12623123. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herold CL, Qi AD, Harden TK, Nicholas RA (2004). "Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop". J. Biol. Chem. 279 (12): 11456–64. doi:10.1074/jbc.M301734200. PMC 1821344 Freely accessible. PMID 14670966. CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cavaliere F, Nestola V, Amadio S; et al. (2005). "The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells". Neurobiol. Dis. 18 (1): 100–9. doi:10.1016/j.nbd.2004.09.001. PMID 15649700. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286 Freely accessible. PMID 15772651. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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