GPR44

edit

G protein-coupled receptor 44
Identifiers
Symbols	GPR44; CD294; CRTH2
External IDs	OMIM: 604837 MGI: 1330275 HomoloGene: 3508 IUPHAR: DP2 GeneCards: GPR44 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • prostaglandin J receptor activity • receptor activity • prostaglandin D receptor activity • prostaglandin F receptor activity • N-formyl peptide receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • chemotaxis • immune response • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase inhibiting pathway • calcium-mediated signaling • positive regulation of G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11251	14764
Ensembl	ENSG00000183134	ENSMUSG00000034117
UniProt	Q9Y5Y4	Q54A00
RefSeq (mRNA)	NM_004778	NM_009962
RefSeq (protein)	NP_004769	NP_034092
Location (UCSC)	Chr 11: 60.37 - 60.38 Mb	Chr 19: 11 - 11.01 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 44 (GPR44) is a human protein. GPR44 has also been designated as CD294 (cluster of differentiation 294).

G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]

GPR44 has recently been found to belong to the prostanoid receptor family and named DP₂, with this becoming the official IUPHAR nomenclature.

Further reading

• Nagata K (2004). "CRTH2". J. Biol. Regul. Homeost. Agents. 17 (4): 334–7. PMID 15065763. 
• Chiba T, Kanda A, Ueki S; et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. doi:10.1159/000101400. PMID 17541272. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagata K, Tanaka K, Ogawa K; et al. (1999). "Selective expression of a novel surface molecule by human Th2 cells in vivo". J. Immunol. 162 (3): 1278–86. PMID 9973380. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marchese A, Sawzdargo M, Nguyen T; et al. (1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai H, Tanaka K, Yoshie O; et al. (2001). "Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2". J. Exp. Med. 193 (2): 255–61. doi:10.1084/jem.193.2.255. PMC 2193345 Freely accessible. PMID 11208866. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai H, Tanaka K, Takano S; et al. (2002). "Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2". J. Immunol. 168 (3): 981–5. PMID 11801628. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwasaki M, Nagata K, Takano S; et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis". J. Invest. Dermatol. 119 (3): 609–16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Böhm E, Sturm GJ, Weiglhofer I; et al. (2004). "11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils". J. Biol. Chem. 279 (9): 7663–70. doi:10.1074/jbc.M310270200. PMID 14668348. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang JL, Gao PS, Mathias RA; et al. (2005). "Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability". Hum. Mol. Genet. 13 (21): 2691–7. doi:10.1093/hmg/ddh279. PMID 15345705. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venet F, Lepape A, Debard AL; et al. (2004). "The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock". Clin. Immunol. 113 (3): 278–84. doi:10.1016/j.clim.2004.07.005. PMID 15507393. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gazi L, Gyles S, Rose J; et al. (2005). "Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes". Prostaglandins Other Lipid Mediat. 75 (1-4): 153–67. doi:10.1016/j.prostaglandins.2004.11.003. PMID 15789622. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hata AN, Lybrand TP, Breyer RM (2005). "Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2". J. Biol. Chem. 280 (37): 32442–51. doi:10.1074/jbc.M502563200. PMID 16030019. CS1 maint: Multiple names: authors list (link)
• Sandig H, Andrew D, Barnes AA; et al. (2006). "9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2". FEBS Lett. 580 (2): 373–9. doi:10.1016/j.febslet.2005.11.052. PMID 16378605. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schratl P, Royer JF, Kostenis E; et al. (2007). "The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking". J. Immunol. 179 (7): 4792–9. PMID 17878378. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "Prostanoid Receptors: DP₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH GPR44+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.