GPR44

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G protein-coupled receptor 44
Identifiers
SymbolsGPR44; CD294; CRTH2
External IDsOMIM604837 MGI1330275 HomoloGene3508 IUPHAR: DP2 GeneCards: GPR44 Gene
RNA expression pattern
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1125114764
EnsemblENSG00000183134ENSMUSG00000034117
UniProtQ9Y5Y4Q54A00
RefSeq (mRNA)NM_004778NM_009962
RefSeq (protein)NP_004769NP_034092
Location (UCSC)Chr 11:
60.37 - 60.38 Mb
Chr 19:
11 - 11.01 Mb
PubMed search[1][2]

G protein-coupled receptor 44 (GPR44) is a human protein.[1] GPR44 has also been designated as CD294 (cluster of differentiation 294).

G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][1]

GPR44 has recently been found to belong to the prostanoid receptor family and named DP2, with this becoming the official IUPHAR nomenclature.

References

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Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. 1.0 1.1 "Entrez Gene: GPR44 G protein-coupled receptor 44".