Cysteinyl leukotriene receptor 1

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Cysteinyl leukotriene receptor 1
Identifiers
SymbolsCYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139
External IDsOMIM300201 MGI1926218 HomoloGene4837 IUPHAR: CysLT1 GeneCards: CYSLTR1 Gene
Orthologs
SpeciesHumanMouse
Entrez1080058861
EnsemblENSG00000173198ENSMUSG00000052821
UniProtQ9Y271Q544P1
RefSeq (mRNA)NM_006639NM_021476
RefSeq (protein)NP_006630NP_067451
Location (UCSC)Chr X:
77.41 - 77.47 Mb
Chr X:
102.78 - 102.78 Mb
PubMed search[1][2]

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.[3]

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

pt:CysLT1
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  3. 3.0 3.1 "Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1".