FZD1

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Frizzled homolog 1 (Drosophila)
Identifiers
Symbols	FZD1; DKFZp564G072
External IDs	OMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: FZD1 GeneCards: FZD1 Gene
Gene Ontology Molecular function • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding Cellular component • membrane • integral to membrane Biological process • G-protein coupled receptor protein signaling pathway • cell-cell signaling • multicellular organismal development • Wnt receptor signaling pathway • epithelial cell differentiation Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8321	14362
Ensembl	ENSG00000157240	ENSMUSG00000044674
UniProt	Q9UP38	Q7TS82
RefSeq (mRNA)	NM_003505	NM_021457
RefSeq (protein)	NP_003496	NP_067432
Location (UCSC)	Chr 7: 90.73 - 90.74 Mb	Chr 5: 4.76 - 4.76 Mb
PubMed search	[1]	[2]

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479 Freely accessible. PMID 9707618. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gazit A, Yaniv A, Bafico A; et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (2002). "The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor". Naunyn Schmiedebergs Arch. Pharmacol. 365 (5): 341–8. doi:10.1007/s00210-002-0540-3. PMID 12012019. CS1 maint: Multiple names: authors list (link)
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1-3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961 Freely accessible. PMID 12690205. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zilberberg A, Yaniv A, Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway". J. Biol. Chem. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301. CS1 maint: Multiple names: authors list (link)
• Wu J, Klein TJ, Mlodzik M (2006). "Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity". PLoS Biol. 2 (7): E158. doi:10.1371/journal.pbio.0020158. PMC 449784 Freely accessible. PMID 15252441. CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang L, Yamasaki K, Shirakata Y; et al. (2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". J. Dermatol. Sci. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.