Prostaglandin F receptor

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Prostaglandin F receptor (FP)
Identifiers
SymbolsPTGFR; FP; MGC120498; MGC46203
External IDsOMIM: 600563 MGI: 97796 HomoloGene: 741 IUPHAR: FP GeneCards: PTGFR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez573719220
EnsemblENSG00000122420ENSMUSG00000028036
UniProtP43088Q60I90
RefSeq (mRNA)NM_000959NM_008966
RefSeq (protein)NP_000950NP_032992
Location (UCSC)Chr 1:
78.54 - 78.78 Mb		Chr 3:
151.74 - 151.77 Mb
PubMed search[1][2]

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.[1]

It is a member of the G-protein coupled receptor family.

Two transcript variants encoding different isoforms have been found for this gene.[1]

Functions

Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis[1], and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters[3].

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[4]

See also

References

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External links

  • "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

  • Duncan AM, Anderson LL, Funk CD; et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Lake S, Gullberg H, Wahlqvist J; et al. (1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor". FEBS Lett. 355 (3): 317–25. PMID 7988697. 
  • Bastien L, Sawyer N, Grygorczyk R; et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • Funk CD, Furci L, FitzGerald GA; et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
  • Abramovitz M, Boie Y, Nguyen T; et al. (1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". J. Biol. Chem. 269 (4): 2632–6. PMID 8300593. 
  • Sugimoto Y, Yamasaki A, Segi E; et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 
  • Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha". J. Biol. Chem. 272 (43): 27147–54. doi:10.1074/jbc.272.43.27147. PMID 9341156. 
  • Betz R, Lagercrantz J, Kedra D; et al. (1999). "Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene". Biochem. Biophys. Res. Commun. 254 (2): 413–6. doi:10.1006/bbrc.1998.9827. PMID 9918852. 
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Neuschäfer-Rube F, Engemaier E, Koch S; et al. (2003). "Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor". Biochem. J. 371 (Pt 2): 443–9. doi:10.1042/BJ20021429. PMC 1223288 Freely accessible. PMID 12519077. 
  • Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). "Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene". Biochim. Biophys. Acta. 1676 (2): 193–202. PMID 14746914. 
  • Sales KJ, Milne SA, Williams AR; et al. (2004). "Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways". J. Clin. Endocrinol. Metab. 89 (2): 986–93. doi:10.1210/jc.2003-031434. PMID 14764825. 
  • Vielhauer GA, Fujino H, Regan JW (2004). "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor". Arch. Biochem. Biophys. 421 (2): 175–85. doi:10.1016/j.abb.2003.10.021. PMID 14984197. 
  • Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279. 
  • Sugino N, Karube-Harada A, Taketani T; et al. (2004). "Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation". J. Reprod. Dev. 50 (2): 215–25. doi:10.1262/jrd.50.215. PMID 15118249. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. 
  • Scott G, Jacobs S, Leopardi S; et al. (2005). "Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation". Exp. Cell Res. 304 (2): 407–16. doi:10.1016/j.yexcr.2004.11.016. PMID 15748887. 
  • Mandal AK, Ray R, Zhang Z; et al. (2005). "Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators". J. Biol. Chem. 280 (38): 32897–904. doi:10.1074/jbc.M502375200. PMID 16061484. 
  • Hébert RL, Carmosino M, Saito O; et al. (2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct". J. Biol. Chem. 280 (41): 35028–37. doi:10.1074/jbc.M505852200. PMID 16096282. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened


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  1. ↑ 1.0 1.1 1.2 "Entrez Gene: PTGFR prostaglandin F receptor (FP)". 
  2. ↑ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 234
  3. ↑ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  4. ↑ Sugimoto Y, Yamasaki A, Segi E; et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889. 
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