MAS1

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MAS1 oncogene
Identifiers
Symbols	MAS1; MAS; MGC119966
External IDs	OMIM: 165180 MGI: 96918 HomoloGene: 1782 IUPHAR: MAS1 GeneCards: MAS1 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • angiotensin type II receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • cell proliferation • anatomical structure morphogenesis Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4142	17171
Ensembl	ENSG00000130368	ENSMUSG00000068037
UniProt	P04201	Q0VB49
RefSeq (mRNA)	NM_002377	XM_622557
RefSeq (protein)	NP_002368	XP_622557
Location (UCSC)	Chr 6: 160.25 - 160.25 Mb	Chr 17: 12.68 - 12.69 Mb
PubMed search	[1]	[2]

MAS proto-oncogene is a protein that in humans is encoded by the MAS1 gene.

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

See also

• MAS1 oncogene

Further reading

• Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". J. Cardiovasc. Pharmacol. 18 Suppl 2: S7–13. PMID 1725048. 
• Hanley MR, Cheung WT, Hawkins P; et al. (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Found. Symp. 150: 23–38; discussion 38–46. PMID 2197067. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rabin M, Birnbaum D, Young D; et al. (1988). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Res. 1 (2): 169–78. PMID 3329713. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jackson TR, Blair LA, Marshall J; et al. (1988). "The mas oncogene encodes an angiotensin receptor". Nature. 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Young D, Waitches G, Birchmeier C; et al. (1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riesewijk AM, Schepens MT, Mariman EM; et al. (1996). "The MAS proto-oncogene is not imprinted in humans". Genomics. 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu X, Quiambao AB, Roveri L; et al. (2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Exp. Neurol. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alenina N, Baranova T, Smirnow E; et al. (2002). "Cell type-specific expression of the Mas proto-oncogene in testis". J. Histochem. Cytochem. 50 (5): 691–6. PMID 11967280. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santos RA, Simoes e Silva AC, Maric C; et al. (2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216 Freely accessible. PMID 12829792. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Canals M, Jenkins L, Kellett E, Milligan G (2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". J. Biol. Chem. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642. CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.