Somatostatin receptor 4

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Somatostatin receptor 4
Identifiers
SymbolsSSTR4;
External IDsOMIM: 182454 MGI: 105372 HomoloGene: 20286 IUPHAR: sst4 GeneCards: SSTR4 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez675420608
EnsemblENSG00000132671ENSMUSG00000037014
UniProtP31391Q8BQ97
RefSeq (mRNA)NM_001052NM_009219
RefSeq (protein)NP_001043NP_033245
Location (UCSC)Chr 20:
22.96 - 22.97 Mb		Chr 2:
148.09 - 148.09 Mb
PubMed search[1][2]

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.[1][2]

{{PBB_Summary | section_title = | summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G spot receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[2] Future studies will likely focus on the alanine content of this structure.

See also

References

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Further reading

  • Patel YC (1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology. 20 (3): 157–98. doi:10.1006/frne.1999.0183. PMID 10433861. 
  • Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214 Freely accessible. PMID 1346068. 
  • Demchyshyn LL, Srikant CB, Sunahara RK; et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Mol. Pharmacol. 43 (6): 894–901. PMID 8100352. 
  • Yasuda K, Espinosa R, Davis EM; et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–6. doi:10.1006/geno.1993.1410. PMID 8244401. 
  • Yamada Y, Kagimoto S, Kubota A; et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420. 
  • Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
  • Yamada Y, Stoffel M, Espinosa R; et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518. 
  • Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochem. Biophys. Res. Commun. 193 (2): 648–52. doi:10.1006/bbrc.1993.1673. PMID 8512564. 
  • Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
  • de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. 
  • Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014. 
  • Forssell-Aronsson EB, Nilsson O, Bejegård SA; et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". J. Nucl. Med. 41 (4): 636–42. PMID 10768564. 
  • Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221. 
  • Talme T, Ivanoff J, Hägglund M; et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108 Freely accessible. PMID 11472428. 
  • Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
  • Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. 

External links

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ 2.0 2.1 "Entrez Gene: SSTR4 somatostatin receptor 4". 
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