EMR2

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Egf-like module containing, mucin-like, hormone receptor-like 2
250px PDB rendering based on 2bo2.
Available structures PDB 2bo2, 2bou, 2box
Identifiers
Symbols	EMR2; CD312; DKFZp781B135
External IDs	OMIM: 606100 HomoloGene: 69138 IUPHAR: EMR2 GeneCards: EMR2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • neuropeptide signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30817	n/a
Ensembl	ENSG00000127507	n/a
UniProt	Q9UHX3	n/a
RefSeq (mRNA)	NM_013447	n/a
RefSeq (protein)	NP_038475	n/a
Location (UCSC)	Chr 19: 14.7 - 14.75 Mb	n/a
PubMed search	[1]	n/a

EGF-like module-containing mucin-like hormone receptor-like 2 is a protein that in humans is encoded by the EMR2 gene. EMR2 has also been designated as CD312 (cluster of differentiation 312).

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms.

See also

• EGF module-containing mucin-like hormone receptor

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin HH, Stacey M, Hamann J; et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin HH, Stacey M, Saxby C; et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex". J. Biol. Chem. 276 (26): 24160–9. doi:10.1074/jbc.M101770200. PMID 11297558. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kwakkenbos MJ, Chang GW, Lin HH; et al. (2002). "The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells". J. Leukoc. Biol. 71 (5): 854–62. PMID 11994511. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stacey M, Chang GW, Davies JQ; et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans". Blood. 102 (8): 2916–24. doi:10.1182/blood-2002-11-3540. PMID 12829604. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang GW, Stacey M, Kwakkenbos MJ; et al. (2003). "Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif". FEBS Lett. 547 (1-3): 145–50. doi:10.1016/S0014-5793(03)00695-1. PMID 12860403. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin HH, Chang GW, Davies JQ; et al. (2004). "Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif". J. Biol. Chem. 279 (30): 31823–32. doi:10.1074/jbc.M402974200. PMID 15150276. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang GW, Davies JQ, Stacey M; et al. (2007). "CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells". Biochem. Biophys. Res. Commun. 353 (1): 133–8. doi:10.1016/j.bbrc.2006.11.148. PMID 17174274. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.