S1PR2

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Sphingosine-1-phosphate receptor 2
Identifiers
SymbolsS1PR2; EDG5; AGR16; EDG-5; Gpcr13; H218; LPB2; S1P2
External IDsOMIM: 605111 MGI: 99569 HomoloGene: 3118 IUPHAR: S1P2 GeneCards: S1PR2 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez929414739
EnsemblENSG00000175898ENSMUSG00000043895
UniProtO95136Q3U5W6
RefSeq (mRNA)NM_004230NM_010333
RefSeq (protein)NP_004221NP_034463
Location (UCSC)Chr 19:
10.2 - 10.2 Mb		Chr 9:
20.72 - 20.73 Mb
PubMed search[1][2]

Sphingosine-1-phosphate receptor 2 also known as S1PR2 or S1P2 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[1]

Function

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[1]

See also

References

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Further reading

  • Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441. 
  • Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348. 
  • MacLennan AJ, Browe CS, Gaskin AA; et al. (1994). "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development". Mol. Cell. Neurosci. 5 (3): 201–9. doi:10.1006/mcne.1994.1024. PMID 8087418. 
  • Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560. 
  • Van Brocklyn JR, Tu Z, Edsall LC; et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698. 
  • Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399. 
  • Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065. 
  • An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617. 
  • Himmel HM, Meyer Zu Heringdorf D, Graf E; et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes". Mol. Pharmacol. 58 (2): 449–54. PMID 10908314. 
  • Hla T. "Sphingosine 1-phosphate receptors". 64 (1-4): 135–142. PMID 11331101. 
  • Mazurais D, Robert P, Gout B; et al. (2002). "Cell type-specific localization of human cardiac S1P receptors". J. Histochem. Cytochem. 50 (5): 661–70. PMID 11967277. 
  • Osada M, Yatomi Y, Ohmori T; et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist". Biochem. Biophys. Res. Commun. 299 (3): 483–7. doi:10.1016/S0006-291X(02)02671-2. PMID 12445827. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Vogler R, Sauer B, Kim DS; et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
  • Kaneider NC, Lindner J, Feistritzer C; et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". Faseb J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Sanchez T, Thangada S, Wu MT; et al. (2005). "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312–7. doi:10.1073/pnas.0409784102. PMID 15764699. 
  • Sanchez T, Skoura A, Wu MT; et al. (2007). "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312–8. doi:10.1161/ATVBAHA.107.143735. PMID 17431187. 

External links

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
  1. ↑ 1.0 1.1 "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2". 
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