GPR182

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G protein-coupled receptor 182
Identifiers
SymbolsGPR182; 7TMR; AMR; MGC34399; gamrh; hrhAMR
External IDsOMIM605307 MGI109545 HomoloGene5255 IUPHAR: GPR182 GeneCards: GPR182 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1131811536
EnsemblENSG00000166856n/a
UniProtO15218n/a
RefSeq (mRNA)NM_007264NM_007412
RefSeq (protein)NP_009195NP_031438
Location (UCSC)Chr 12:
55.67 - 55.68 Mb
n/a
PubMed search[1][2]

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.[1]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.[2] However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).[3]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.[4]

References

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Further reading

  • Lah JJ, Frishman WH (2002). "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential". Heart disease (Hagerstown, Md.). 2 (3): 259–65. PMID 11728267. 
  • Mukoyama M, Sugawara A, Nagae T; et al. (2002). "Role of adrenomedullin and its receptor system in renal pathophysiology". Peptides. 22 (11): 1925–31. doi:10.1016/S0196-9781(01)00525-3. PMID 11754983. 
  • Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review)". Int. J. Mol. Med. 9 (5): 443–9. PMID 11956648. 
  • Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells". Eur. J. Pharmacol. 289 (2): 383–5. doi:10.1016/0922-4106(95)90117-5. PMID 7621913. 
  • Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). "Adrenomedullin receptor expression in human lung and in pulmonary tumors". J. Histochem. Cytochem. 45 (2): 159–64. PMID 9016306. 
  • Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–8. doi:10.1006/bbrc.1997.7631. PMID 9367907. 
  • Martínez A, Elsasser TH, Muro-Cacho C; et al. (1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument". Endocrinology. 138 (12): 5597–604. doi:10.1210/en.138.12.5597. PMID 9389548. 
  • Kennedy SP, Sun D, Oleynek JJ; et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–7. doi:10.1006/bbrc.1998.8349. PMID 9535752. 
  • Jiménez N, Calvo A, Martínez A; et al. (1999). "Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate". J. Histochem. Cytochem. 47 (9): 1167–78. PMID 10449538. 
  • Kuwasako K, Kitamura K, Ito K; et al. (2002). "The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors". J. Biol. Chem. 276 (52): 49459–65. doi:10.1074/jbc.M108369200. PMID 11591721. 
  • Forneris M, Gottardo L, Albertin G; et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells". Int. J. Mol. Med. 8 (6): 675–9. PMID 11712085. 
  • Hänze J, Groneberg DA, Rose F; et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia". Biochem. Biophys. Res. Commun. 291 (5): 1160–5. doi:10.1006/bbrc.2002.6595. PMID 11883938. 
  • Dumont CE, Muff R, Flühmann B; et al. (2003). "Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats". Brain Res. 955 (1-2): 64–71. doi:10.1016/S0006-8993(02)03365-6. PMID 12419522. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 
  • Chosa E, Hamada H, Kitamura K; et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells". Biochem. Biophys. Res. Commun. 303 (1): 379–86. doi:10.1016/S0006-291X(03)00347-4. PMID 12646214. 
  • Xu P, Dai AG, Zhou HD; et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi. 26 (12): 765–8. PMID 14720432. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928Freely accessible. PMID 15489334. 

External links

  • "GPR182". IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. Retrieved 2008-07-03. 
sr:GPR182
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