GPR77

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G protein-coupled receptor 77
Identifiers
SymbolsGPR77; C5L2; GPF77
External IDsOMIM609949 MGI2442013 HomoloGene49549 IUPHAR: C5L2 GeneCards: GPR77 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez27202319430
EnsemblENSG00000134830ENSMUSG00000074361
UniProtQ9P296n/a
RefSeq (mRNA)NM_018485NM_176912
RefSeq (protein)NP_060955NP_795886
Location (UCSC)Chr 19:
52.54 - 52.54 Mb
Chr 7:
15.4 - 15.4 Mb
PubMed search[1][2]

C5a anaphylatoxin chemotactic receptor C5L2 is a protein that in humans is encoded by the GPR77 gene.[1][2]

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005).[supplied by OMIM][2]

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  2. 2.0 2.1 "Entrez Gene: GPR77 G protein-coupled receptor 77".