LPAR2
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lysophosphatidic acid receptor 2 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | LPAR2; EDG4; EDG-4; LPA2 | ||||||||||||
External IDs | OMIM: 605110 MGI: 1858422 HomoloGene: 3465 IUPHAR: LPA2 GeneCards: LPAR2 Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
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More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 9170 | 53978 | |||||||||||
Ensembl | ENSG00000064547 | ENSMUSG00000031861 | |||||||||||
UniProt | Q9HBW0 | Q9JL06 | |||||||||||
RefSeq (mRNA) | NM_004720 | NM_020028 | |||||||||||
RefSeq (protein) | NP_004711 | NP_064412 | |||||||||||
Location (UCSC) | Chr 19: 19.6 - 19.6 Mb | Chr 8: 72.75 - 72.76 Mb | |||||||||||
PubMed search | [1] | [2] |
Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene.[1][2][3] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]
Function
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[1]
Interactions
LPAR2 has been shown to interact with TRIP6.[5]
See also
References
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Further reading
- Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.
- Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753.
- Goetzl EJ, Dolezalova H, Kong Y; et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.
- Contos JJ, Chun J (2000). "Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA". Genomics. 64 (2): 155–69. doi:10.1006/geno.2000.6122. PMID 10729222.
- Bandoh K, Aoki J, Taira A; et al. (2000). "Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors". FEBS Lett. 478 (1-2): 159–65. doi:10.1016/S0014-5793(00)01827-5. PMID 10922489.
- Young KW, Bootman MD, Channing DR; et al. (2001). "Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors". J. Biol. Chem. 275 (49): 38532–9. doi:10.1074/jbc.M006631200. PMID 10954727.
- Zheng Y, Voice JK, Kong Y, Goetzl EJ (2001). "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes". Faseb J. 14 (15): 2387–9. doi:10.1096/fj.00-0492fje. PMID 11024010.
- Hama K, Bandoh K, Kakehi Y; et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1-3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Fujita T, Miyamoto S, Onoyama I; et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer". Cancer Lett. 192 (2): 161–9. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280.
- Hu YL, Albanese C, Pestell RG, Jaffe RB (2003). "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells". J. Natl. Cancer Inst. 95 (10): 733–40. PMID 12759391.
- Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Oh YS, Jo NW, Choi JW; et al. (2004). "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation". Mol. Cell. Biol. 24 (11): 5069–79. doi:10.1128/MCB.24.11.5069-5079.2004. PMID 15143197.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
External links
- "Lysophospholipid Receptors: LPA2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH Lysophospholipid+receptors
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- ↑ 1.0 1.1 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
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