Thyrotropin-releasing hormone receptor

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Thyrotropin-releasing hormone receptor
Identifiers
SymbolsTRHR; MGC141920
External IDsOMIM: 188545 MGI: 98824 HomoloGene: 20707 IUPHAR: TRH1 GeneCards: TRHR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez720122045
EnsemblENSG00000174417ENSMUSG00000038760
UniProtP34981Q32MS1
RefSeq (mRNA)NM_003301NM_013696
RefSeq (protein)NP_003292NP_038724
Location (UCSC)Chr 8:
110.17 - 110.2 Mb		Chr 15:
44.03 - 44.06 Mb
PubMed search[1][2]

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[1][2] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.

References

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Further reading

  • Short RE, James LF, Panter KE; et al. (1993). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep". J. Anim. Sci. 70 (11): 3498–504. PMID 1459912. 
  • Yamada M, Iwasaki T, Satoh T; et al. (1996). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly". Neurosci. Lett. 196 (1-2): 109–12. doi:10.1016/0304-3940(95)11861-P. PMID 7501234. 
  • Hinuma S, Hosoya M, Ogi K; et al. (1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene". Biochim. Biophys. Acta. 1219 (2): 251–9. PMID 7918619. 
  • Morrison N, Duthie SM, Boyd E; et al. (1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization". Hum. Genet. 93 (6): 716–8. PMID 8005602. 
  • Yamada M, Monden T, Konaka S, Mori M (1994). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somat. Cell Mol. Genet. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317. 
  • Duthie SM, Taylor PL, Anderson L; et al. (1994). "Cloning and functional characterisation of the human TRH receptor". Mol. Cell. Endocrinol. 95 (1-2): R11–5. doi:10.1016/0303-7207(93)90043-J. PMID 8243797. 
  • Matre V, Karlsen HE, Wright MS; et al. (1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor". Biochem. Biophys. Res. Commun. 195 (1): 179–85. doi:10.1006/bbrc.1993.2027. PMID 8395824. 
  • Yamada M, Monden T, Satoh T; et al. (1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene". Biochem. Biophys. Res. Commun. 195 (2): 737–45. doi:10.1006/bbrc.1993.2107. PMID 8396925. 
  • Iwasaki T, Yamada M, Satoh T; et al. (1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene". J. Biol. Chem. 271 (36): 22183–8. doi:10.1074/jbc.271.36.22183. PMID 8703031. 
  • Cook JV, McGregor A, Lee T; et al. (1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor". Endocrinology. 137 (7): 2851–8. doi:10.1210/en.137.7.2851. PMID 8770906. 
  • Collu R, Tang J, Castagné J; et al. (1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene". J. Clin. Endocrinol. Metab. 82 (5): 1561–5. doi:10.1210/jc.82.5.1561. PMID 9141550. 
  • Petrou C, Tashjian AH (1999). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cell. Signal. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3. PMID 9794253. 
  • Matre V, Høvring PI, Orstavik S; et al. (1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor". J. Neurochem. 72 (1): 40–50. doi:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052. 
  • Kroeger KM, Hanyaloglu AC, Seeber RM; et al. (2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer". J. Biol. Chem. 276 (16): 12736–43. doi:10.1074/jbc.M011311200. PMID 11278883. 
  • Zhu CC, Cook LB, Hinkle PM (2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation". J. Biol. Chem. 277 (31): 28228–37. doi:10.1074/jbc.M204221200. PMID 12023974. 
  • Hanyaloglu AC, Seeber RM, Kohout TA; et al. (2003). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2". J. Biol. Chem. 277 (52): 50422–30. doi:10.1074/jbc.M209340200. PMID 12393857. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Cook LB, Zhu CC, Hinkle PM (2004). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation". Mol. Endocrinol. 17 (9): 1777–91. doi:10.1210/me.2003-0073. PMID 12805411. 
  • Igarashi-Migitaka J, Yamada S, Hara M; et al. (2004). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas". Endocr. J. 50 (4): 459–67. doi:10.1507/endocrj.50.459. PMID 14599121. 
  • Cook LB, Hinkle PM (2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein". Endocrinology. 145 (7): 3095–100. doi:10.1210/en.2004-0304. PMID 15117874. 

External links

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
Hormone receptors
CRH - FSH - LHRH - TRH - Somatostatin
Other
Opioid receptors
Other neuropeptide receptors
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  1. ↑ Yamada M, Monden T, Konaka S, Mori M (1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somat. Cell Mol. Genet. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317. 
  2. ↑ Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: cloning and regulation of its expression". Recent Prog. Horm. Res. 48: 341–63. PMID 8382829. 
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