FZD3

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Frizzled homolog 3 (Drosophila)
Identifiers
Symbols	FZD3; Fz-3; hFz3
External IDs	OMIM: 606143 MGI: 108476 HomoloGene: 23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding • Wnt receptor activity Cellular component • integral to plasma membrane • membrane • apical part of cell Biological process • establishment of planar polarity • neural tube closure • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development • cell proliferation • inner ear morphogenesis Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7976	14365
Ensembl	ENSG00000104290	ENSMUSG00000007989
UniProt	Q9NPG1	Q3TUV1
RefSeq (mRNA)	NM_017412	NM_021458
RefSeq (protein)	NP_059108	NP_067433
Location (UCSC)	Chr 8: 28.41 - 28.49 Mb	Chr 14: 64.16 - 64.22 Mb
PubMed search	[1]	[2]

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974. 
• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233 Freely accessible. PMID 9192640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302. CS1 maint: Multiple names: authors list (link)
• Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katsu T, Ujike H, Nakano T; et al. (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Yu X, Yuan Y; et al. (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 Freely accessible. PMID 15340161. 
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto R, Suzuki T, Iwata N; et al. (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders". Journal of neural transmission (Vienna, Austria : 1996). 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.