Melatonin receptor 1A

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Melatonin receptor 1A
Identifiers
SymbolsMTNR1A; MT1; MEL-1A-R
External IDsOMIM: 600665 MGI: 102967 HomoloGene: 21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez454317773
EnsemblENSG00000168412ENSMUSG00000054764
UniProtP48039Q14AC3
RefSeq (mRNA)NM_005958XM_991330
RefSeq (protein)NP_005949XP_996424
Location (UCSC)Chr 4:
187.69 - 187.71 Mb		Chr 8:
46.57 - 46.59 Mb
PubMed search[1][2]

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.[1][2]

This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.[2]

See also

References

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External links

  • "Melatonin Receptors: MT1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

  • Brzezinski A; Brzezinski, Amnon (1997). "Melatonin in humans". N. Engl. J. Med. 336 (3): 186–95. doi:10.1056/NEJM199701163360306. PMID 8988899. 
  • Khan AU, Olson DL (1975). "Physical therapy and exercise-induced bronchospasm". Physical therapy. 55 (8): 878–81. PMID 1144527. 
  • Reppert SM, Weaver DR, Ebisawa T (1994). "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses". Neuron. 13 (5): 1177–85. doi:10.1016/0896-6273(94)90055-8. PMID 7946354. 
  • Witt-Enderby PA, Dubocovich ML (1996). "Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells". Mol. Pharmacol. 50 (1): 166–74. PMID 8700109. 
  • Witt-Enderby PA, Masana MI, Dubocovich ML (1998). "Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor". Endocrinology. 139 (7): 3064–71. doi:10.1210/en.139.7.3064. PMID 9645677. 
  • Ebisawa T, Kajimura N, Uchiyama M; et al. (1999). "Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders". Biochem. Biophys. Res. Commun. 262 (3): 832–7. doi:10.1006/bbrc.1999.1308. PMID 10471411. 
  • Brydon L, Roka F, Petit L; et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579. 
  • Niles LP, Wang J, Shen L; et al. (2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1-2): 107–10. doi:10.1016/S0303-7207(99)00135-5. PMID 10612428. 
  • Song CK, Bartness TJ (2001). "CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity". Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666–72. PMID 11448873. 
  • Roy D, Angelini NL, Fujieda H; et al. (2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology. 142 (11): 4711–20. doi:10.1210/en.142.11.4711. PMID 11606436. 
  • Savaskan E, Olivieri G, Meier F; et al. (2002). "Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients". J. Pineal Res. 32 (1): 59–62. doi:10.1034/j.1600-079x.2002.00841.x. PMID 11841602. 
  • Savaskan E, Wirz-Justice A, Olivieri G; et al. (2002). "Distribution of melatonin MT1 receptor immunoreactivity in human retina". J. Histochem. Cytochem. 50 (4): 519–26. PMID 11897804. 
  • Ayoub MA, Couturier C, Lucas-Meunier E; et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". J. Biol. Chem. 277 (24): 21522–8. doi:10.1074/jbc.M200729200. PMID 11940583. 
  • Yuan L, Collins AR, Dai J; et al. (2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Mol. Cell. Endocrinol. 192 (1-2): 147–56. doi:10.1016/S0303-7207(02)00029-1. PMID 12088876. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Slominski A, Pisarchik A, Zbytek B; et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53. doi:10.1002/jcp.10287. PMID 12767050. 
  • Morcuende JA, Minhas R, Dolan L; et al. (2004). "Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis". Spine. 28 (17): 2025–8; discussion 2029. doi:10.1097/01.BRS.0000083235.74593.49. PMID 12973153. 
  • Aust S, Thalhammer T, Humpeler S; et al. (2004). "The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia". J. Pineal Res. 36 (1): 43–8. doi:10.1046/j.1600-079X.2003.00095.x. PMID 14675129. 
40x30px This transmembrane receptor-related article is a stub. You can help ssf by expanding it.
Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
es:Receptor de melatonina 1A
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ 2.0 2.1 "Entrez Gene: MTNR1A melatonin receptor 1A". 
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