Urotensin-II receptor

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Urotensin 2 receptor
Identifiers
Symbols	UTS2R; GPR14; UTR; UTR2
External IDs	OMIM: 600896 MGI: 2183450 HomoloGene: 10345 IUPHAR: UT GeneCards: UTS2R Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • urotensin II receptor activity • receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • circulation Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	2837	217369
Ensembl	ENSG00000181408	ENSMUSG00000039321
UniProt	Q9UKP6	Q05AD1
RefSeq (mRNA)	NM_018949	NM_145440
RefSeq (protein)	NP_061822	NP_663415
Location (UCSC)	Chr 17: 77.93 - 77.93 Mb	Chr 11: 120.98 - 120.98 Mb
PubMed search	[1]	[2]

The urotensin-II receptor (UT, also referred to as the hypocretin receptor) is a G-protein coupled receptor which binds the peptide hormone urotensin-II.

Further reading

• Marchese A, Heiber M, Nguyen T; et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coulouarn Y, Lihrmann I, Jegou S; et al. (1999). "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15803–8. doi:10.1073/pnas.95.26.15803. PMC 28125 Freely accessible. PMID 9861051. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ames RS, Sarau HM, Chambers JK; et al. (1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. doi:10.1038/45809. PMID 10499587. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Q, Pong SS, Zeng Z; et al. (2000). "Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14". Biochem. Biophys. Res. Commun. 266 (1): 174–8. doi:10.1006/bbrc.1999.1796. PMID 10581185. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Protopopov A, Kashuba V, Podowski R; et al. (2000). "Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 88 (3-4): 312–3. doi:10.1159/000015516. PMID 10828617. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maguire JJ, Kuc RE, Davenport AP (2001). "Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1". Br. J. Pharmacol. 131 (3): 441–6. doi:10.1038/sj.bjp.0703601. PMC 1572358 Freely accessible. PMID 11015293. CS1 maint: Multiple names: authors list (link)
• Sugo T, Murakami Y, Shimomura Y; et al. (2003). "Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain". Biochem. Biophys. Res. Commun. 310 (3): 860–8. doi:10.1016/j.bbrc.2003.09.102. PMID 14550283. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Birker-Robaczewska M, Boukhadra C, Studer R; et al. (2004). "The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma". J. Recept. Signal Transduct. Res. 23 (4): 289–305. doi:10.1081/RRS-120026972. PMID 14753294. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bousette N, Patel L, Douglas SA; et al. (2004). "Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta". Atherosclerosis. 176 (1): 117–23. doi:10.1016/j.atherosclerosis.2004.03.023. PMID 15306183. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki S, Wenyi Z, Hirai M; et al. (2005). "Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese". Peptides. 25 (10): 1803–8. doi:10.1016/j.peptides.2004.03.030. PMID 15476949. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qi JS, Minor LK, Smith C; et al. (2005). "Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors". Peptides. 26 (4): 683–90. doi:10.1016/j.peptides.2004.11.018. PMID 15752584. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner U, Velić A, Schroter R; et al. (2007). "Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells". Cell. Physiol. Biochem. 20 (1-4): 181–92. doi:10.1159/000104165. PMID 17595527. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Segain JP, Rolli-Derkinderen M, Gervois N; et al. (2007). "Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes". J. Immunol. 179 (2): 901–9. PMID 17617581. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehmann F, Pettersen A, Currier EA, Sherbukin, V, Olsson R, Hacksell U, Luthman K (2006). "Novel potent and efficacious Urotensin II receptor agonists". J. Med. Chem. 49 (7): 2232–40. doi:10.1021/jm051121i. PMID 16570919. CS1 maint: Multiple names: authors list (link)

External links

• "Urotensin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH UTS2R+protein,+human