P2RY8

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Purinergic receptor P2Y, G-protein coupled, 8
Identifiers
Symbols	P2RY8; MGC50878; P2Y8
External IDs	OMIM: 300525 HomoloGene: 65345 IUPHAR: P2RY8 GeneCards: P2RY8 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	286530	n/a
Ensembl	ENSG00000182162	n/a
UniProt	Q86VZ1	n/a
RefSeq (mRNA)	NM_178129	n/a
RefSeq (protein)	NP_835230	n/a
Location (UCSC)	Chr X: 1.54 - 1.62 Mb	n/a
PubMed search	[1]	n/a

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.

See also

• P2Y receptor

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantagrel V, Lossi AM, Boulanger S; et al. (2005). "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males". J. Med. Genet. 41 (10): 736–42. doi:10.1136/jmg.2004.021626. PMC 1735597 Freely accessible. PMID 15466006. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286 Freely accessible. PMID 15772651. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujiwara S, Yamashita Y, Choi YL; et al. (2007). "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening". Leuk. Lymphoma. 48 (5): 978–86. doi:10.1080/10428190701225882. PMID 17487742. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Storlazzi CT, Albano F, Lo Cunsolo C; et al. (2007). "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma". Leukemia. 21 (10): 2221–5. doi:10.1038/sj.leu.2404784. PMID 17554380. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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